Andrew Guzman values mitigation over adaptation. In his book Overheated: The Human Cost of Climate Change, Guzman took a unique approach by focusing on the actual effects of climate disruption has on nations and societies, rather than rehashing debates about science or policy. As a professor of law at UC Berkeley Law School, he has written extensively on international trade, international regulatory matters, and foreign direct investment.

Guzman has taught as a visiting professor at Harvard Law School, the University of Chicago Law School, the University of Virginia Law School, Vanderbilt Law School, the University of Hamburg, and the National University Law School in Bangalore, India.